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Trial Results

BACKGROUND: There isn't any effective topical treatment available for treating all pathogenic factors that cause acne vulgaris (AV). Tretinoin (all-TRA), Salicylic acid (SA) and clindamycin phosphate (CDP) are known to be effective agents depending on their anti-inflammatory and comedolytic elements.

GOAL: The main goal was to compare the efficiency and tolerability of SA and CDP combination (SA+CDP) with all-TRA and CDP (all-TRA+CDP) in individuals with mild-moderate facial AV.

PROCEDURES: 46 individuals (ages between 18 -35) were enrolled in a 12-week prospective, single-blind, randomized and comparative test study. It was evaluated the efficiency by lesion counts, general improvement, quality of life and measurement of skin barrier functions. Side effects were also taken under evaluation.

RESULTS: It was reported that both combinations were effective in reducing total lesion (TL), non-inflammatory lesion (NIL) and inflammatory lesion (IL) counts. Moreover, they presented considerable general improvement as evaluated by the investigator. When tests ended, there was no significant difference between the two groups in regards to all lesion counts. Also, TL counts decreased faster in the all-TRA+CDP group when compared with those in the SA+CDP group, with a considerable difference between the two groups as early as 2 weeks. Evaluations regarding safety showed that the incidence of mild-moderate side effects generally peaked at week 2 period and started to decline gradually thereafter. Both combinations did not have an effect on stratum corneum hydration, although skin sebum values decreased with SA+CDP treatment.

VERDICT: It was determined that combination of SA+CDP and all-TRA+CDP was effective in lowering lesion counts and well tolerated with minimal local cutaneous reactions in individuals with mild to moderate AV. (c) 2010 The Authors. Journal of the European Academy of Dermatology and Venereology (c) 2010 European Academy of Dermatology and Venereology.